Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation

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Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation

Cystic fibrosis (CF) pulmonary disease is characterized by chronic airway infection and inflammation. The infectious and inflamed CF airway environment impacts on the innate defense of airway epithelia and airway macrophages. The CF airway milieu induces an adaptation in these cells characterized by increased basal inflammation and a robust inflammatory response to inflammatory mediators. Recen...

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1Lung Innate Immunity Research Laboratory, Program in Physiology & Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 0A4 2Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada M5G 0A4 3Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada M5S 1A8 4Department of Translational Pulmonology, D...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2017

ISSN: 1422-0067

DOI: 10.3390/ijms18010118