Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
نویسندگان
چکیده
منابع مشابه
Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
Cystic fibrosis (CF) pulmonary disease is characterized by chronic airway infection and inflammation. The infectious and inflamed CF airway environment impacts on the innate defense of airway epithelia and airway macrophages. The CF airway milieu induces an adaptation in these cells characterized by increased basal inflammation and a robust inflammatory response to inflammatory mediators. Recen...
متن کاملNew Developments in Cystic Fibrosis Airway Inflammation
1Lung Innate Immunity Research Laboratory, Program in Physiology & Experimental Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 0A4 2Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada M5G 0A4 3Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada M5S 1A8 4Department of Translational Pulmonology, D...
متن کاملMechanisms and markers of airway inflammation in cystic fibrosis.
Airway inflammation is now recognized as a major factor in the pathogenesis of lung disease in cystic fibrosis (CF). Its most characteristic feature is a marked and persistent influx into the airways of neutrophils, which damage the lung by releasing noxious mediators, such as reactive oxygen species and proteolytic enzymes. Recent studies suggest that inflammation occurs very early and may eve...
متن کاملCYSTIC FIBROSIS Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis
Background: Cystic fibrosis (CF) airways are characterised by chronic inflammation, increased interleukin (IL)-8 secretion, and neutrophil activation which are considered the principal factors of morbidity and mortality in CF patients. Optimising management of this chronic inflammatory response is therefore a key issue of basic and clinical CF research. Several reports have addressed ways to ma...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2017
ISSN: 1422-0067
DOI: 10.3390/ijms18010118